Cerebral Energy Metabolism in Cyanide Encephalopathy

Cerebral energy metabolism in isovaleric acidaemia.

A newborn infant with an acute metabolic encephalopathy caused by isovaleric acidaemia had severe impairment of cerebral energy metabolism. This was detected by phosphorus and proton magnetic resonance spectroscopy. After treatment she made excellent clinical recovery, her spectroscopic abnormalities resolved, and she was neurologically normal at the age of 1 year.

Cerebral energy metabolism after subarachnoid hemorrhage.

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Combined administration of hyperbaric oxygen and hydroxocobalamin improves cerebral metabolism after acute cyanide poisoning in rats.

Hyperbaric oxygen therapy (HBOT) or intravenous hydroxocobalamin (OHCob) both abolish cyanide (CN)-induced surges in interstitial brain lactate and glucose concentrations. HBOT has been shown to induce a delayed increase in whole blood CN concentrations, whereas OHCob may act as an intravascular CN scavenger. Additionally, HBOT may prevent respiratory distress and restore blood pressure during ...

Ethylene biosynthesis in relation to cyanide metabolism

Cyanide is a co-product of ethylene biosynthesis in higher plants via the ACC pathway. In certain physiological states, such as fruit ripening and flower senescence, and in many environmental conditions, such as flooding and chilling, ethylene biosynthesis is greatly induced. Cyanide is toxic to plants if it accumulates in plant tissues; however, during fruit ripening, the co-product cyanide is...

Cerebral blood flow and energy metabolism in vascular insufficiency.